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Serum 25-hydroxyvitamin D, calcium, and calcium-regulating hormones in preeclamptics and controls during first day postpartum

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Abstract

The evidence for a link between vitamin D and preeclampsia is conflicting. There is a paucity of studies reporting simultaneous 25-hydroxyvitamin D (inactive form) and 1,25-dihydroxyvitamin D (biologically active form). We investigated if levels of serum 25-hydroxyvitamin D, calcium-regulating hormones (1,25-dihydroxyvitamin D, parathyroid hormone), and calcium differ significantly between preeclamptics and controls. On postpartum day one, 98 subjects (44 with preeclampsia, 54 controls) were recruited among women admitted to the postdelivery unit, and their serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone, serum calcium, and serum albumin levels were prospectively measured. The majority of participants (70 %) had serum 25-hydroxyvitamin D level <20 ng/mL; 53 % had <15 ng/mL. Mean serum 25-hydroxyvitamin D level was similar between cases and controls (p = 0.50). Mean total serum calcium adjusted for albumin and magnesium was similar between cases and controls (p = 0.78). Mean serum 1,25-dihydroxyvitamin D and parathyroid hormone levels were normal, and there were no differences between cases and controls. The only significant differences found between preeclamptic cases and controls were mean body mass index, parity, and season of blood draw. Vitamin D levels did not differ among preeclamptic cases and controls.

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References

  1. J. Uzan, M. Carbonnel, O. Piconne, R. Asmar, J.M. Ayoubi, Pre-eclampsia: pathophysiology, diagnosis, and management. Vasc. Health Risk Manag. 7, 467–474 (2011)

    PubMed Central  PubMed  Google Scholar 

  2. M.L. Mulligan, S.K. Felton, A.E. Riek, C. Bernal-Mizrachi, Implications of vitamin D deficiency in pregnancy and lactation. Am. J. Obstet. Gynecol. 202(429), e1–e9 (2010)

    PubMed  Google Scholar 

  3. H. Barrett, A. McElduff, Vitamin D and pregnancy: an old problem revisited. Best Pract. Res. Clin. Endocrinol. Metab. 24, 527–539 (2010)

    Article  CAS  PubMed  Google Scholar 

  4. T.D. Thacher, B.L. Clarke, Vitamin D insufficiency. Mayo Clin. Proc. 86, 50–60 (2011)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Y. Zhou, C.H. Damsky, K. Chiu, J.M. Roberts, S.J. Fisher, Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts. J. Clin. Invest. 91, 950–960 (1993)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. J.P. Granger, B.T. Alexander, M.T. Llinas, W.A. Bennett, R.A. Khalil, Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction. Microcirculation 9, 147–160 (2002)

    Article  CAS  PubMed  Google Scholar 

  7. M.F. Holick, Vitamin D deficiency. N. Engl. J. Med. 357, 266–281 (2007)

    Article  CAS  PubMed  Google Scholar 

  8. L.M. Bodnar, J.M. Catov, H.N. Simhan, M.F. Holick, R.W. Powers, J.M. Roberts, Maternal vitamin D deficiency increases the risk of preeclampsia. J. Clin. Endocrinol. Metab. 92, 3517–3522 (2007)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. A.M. Baker, S. Haeri, C.A. Camargo Jr, J.A. Espinola, A.M. Stuebe, A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J. Clin. Endocrinol. Metab. 95, 5105–5109 (2010)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. C.J. Robinson, M.C. Alanis, C.L. Wagner, B.W. Hollis, D.D. Johnson, Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. Am. J. Obstet. Gynecol. 203(366), e1–e6 (2010)

    Google Scholar 

  11. S. Wei, F. Audibert, N. Hidiroglou, K. Sarafin, P. Julien, Y. Wu, Z.C. Luo, W.D. Fraser, Longitudinal vitamin D status in pregnancy and the risk of pre-eclampsia. BJOG 119, 832–839 (2012)

    Article  CAS  PubMed  Google Scholar 

  12. S.Q. Wei, H.P. Qi, Z.C. Luo, W.D. Fraser, Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. J. Matern. Fetal. Neonatal 26, 889–899 (2013)

    Article  CAS  Google Scholar 

  13. M. Tabesh, A. Salehi-Abargouei, A. Esmaillzadeh, Maternal vitamin D status and risk of pre-eclampsia: a systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 98, 3165–3173 (2013)

    Article  CAS  PubMed  Google Scholar 

  14. B.M. Schroeder, ACOG practice bulletin on diagnosing and managing preeclampsia and eclampsia. American College of Obstetricians and Gynecologists. Am. Fam. Physician 66, 330–331 (2002)

    PubMed  Google Scholar 

  15. R.L. Olson, J. Gaylor, M.A. Everett, Skin color, melanin, and erythema. Arch. Dermatol. 108, 541–544 (1973)

    Article  CAS  PubMed  Google Scholar 

  16. J.M. Belizán, J. Villar, The relationship between calcium intake and edema-, proteinuria-, and hypertension-getosis: an hypothesis. Am. J. Clin. Nutr. 33, 2202–2210 (1980)

    PubMed  Google Scholar 

  17. G.J. Hofmeyr, T.A. Lawrie, A.N. Atallah, L. Duley, Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst. Rev. 4(8), CD001059 (2010)

    Google Scholar 

  18. R.J. Levine, J.C. Hauth, L.B. Curet, B.M. Sibai, P.M. Catalano, C.D. Morris, R. DerSimonian, J.R. Esterlitz, E.G. Raymond, D.E. Bild, J.D. Clemens, J.A. Cutler, Trial of calcium to prevent preeclampsia. N. Engl. J. Med. 337, 69–76 (1997)

    Article  CAS  PubMed  Google Scholar 

  19. T.S. Patrelli, A. Dall’asta, S. Gizzo, G. Pedrazzi, G. Piantelli, V.M. Jasonni, A.B. Modena, Calcium supplementation and prevention of preeclampsia: a meta-analysis. J. Matern. Fetal Neonatal Med. 25, 2570–2574 (2012)

    Article  CAS  PubMed  Google Scholar 

  20. C.E. Powe, E.W. Seely, S. Rana, I. Bhan, J. Ecker, S.A. Karumanchi, R. Thadhani, First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension 56, 758–763 (2010)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  21. R.B. Payne, A.J. Little, R.T. Evans, Albumin-adjusted calcium concentration in serum increases during normal pregnancy. Clin. Chem. 36, 142–144 (1990)

    CAS  PubMed  Google Scholar 

  22. D.A. Bushinsky, R.D. Monk, Electrolyte quintet: calcium. Lancet 352, 306–311 (1998)

    Article  CAS  PubMed  Google Scholar 

  23. D.P. Cruikshank, G.M. Chan, D. Doerrfeld, Alterations in vitamin D and calcium metabolism with magnesium sulfate treatment of preeclampsia. Am. J. Obstet. Gynecol. 168, 1170–1176 (1993). discussion 1176–1177

    Article  CAS  PubMed  Google Scholar 

  24. M. Leu, E. Giovannucci, Vitamin D: epidemiology of cardiovascular risks and events. Best Pract. Res. Clin. Endocrinol. Metab. 25, 633–646 (2011)

    Article  CAS  PubMed  Google Scholar 

  25. V. Carnevale, R. Minonne, A. De Matthaeis, M.A. Annese, P. Tabacco, P. D’Arcangelo, G. D’Amico, A. Scillitani, Carotid intima-media thickness is not associated with vitamin D and PTH levels in patients admitted to an Internal Medicine Department. Endocrine (2014). doi:10.1007/s12020-014-0191-4

    Google Scholar 

  26. E.W. Seely, Calciotropic hormones in preeclampsia: a renewal of interest. J. Clin. Endocrinol. Metab. 92, 3402–3403 (2007)

    Article  CAS  PubMed  Google Scholar 

  27. H.J. van den Elzen, J.W. Wladimiroff, T.E. Overbeek, C.D. Morris, D.E. Grobbee, Calcium metabolism, calcium supplementation and hypertensive disorders of pregnancy. Eur. J. Obstet. Gynecol. Reprod. Biol. 59, 5–16 (1995)

    Article  PubMed  Google Scholar 

  28. R. Kumar, W.R. Cohen, P. Silva, F.H. Epstein, Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation. J. Clin. Invest. 63, 342–344 (1979)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  29. E.W. Seely, E.M. Brown, D.M. DeMaggio, D.K. Weldon, S.W. Graves, A prospective study of calciotropic hormones in pregnancy and post partum: reciprocal changes in serum intact parathyroid hormone and 1,25-dihydroxyvitamin D. Am. J. Obstet. Gynecol. 176, 214–217 (1997)

    Article  CAS  PubMed  Google Scholar 

  30. I.N. Cholst, S.F. Steinberg, P.J. Tropper, H.E. Fox, G.V. Segre, J.P. Bilezikian, The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects. N. Engl. J. Med. 310, 1221–1225 (1984)

    Article  CAS  PubMed  Google Scholar 

  31. K. Suzuki, K. Nonaka, N. Kono, K. Ichihara, Y. Fukumoto, Y. Inui, J. Miyagawa, T. Onishi, C. Hayashi, S. Tarui, Effects of the intravenous administration of magnesium sulfate on corrected serum calcium level and nephrogenous cyclic AMP excretion in normal human subjects. Calcif. Tissue Int. 39, 304–309 (1986)

    Article  CAS  PubMed  Google Scholar 

  32. R.B. Payne, M.E. Carver, D.B. Morgan, Interpretation of serum total calcium: effects of adjustment for albumin concentration on frequency of abnormal values and on detection of change in the individual. J. Clin. Pathol. 32, 56–60 (1979)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  33. M. Gojnic, S. Petkovic, M. Papic, T. Mostic, K. Jeremic, Z. Vilendecic, S. Djordjevic, Plasma albumin level as an indicator of severity of preeclampsia. Clin. Exp. Obstet. Gynecol. 31, 209–210 (2004)

    CAS  PubMed  Google Scholar 

  34. D.P. Cruikshank, R.M. Pitkin, W.A. Reynolds, G.A. Williams, G.K. Hargis, Effects of magnesium sulfate treatment on perinatal calcium metabolism. I. Maternal and fetal responses. Am. J. Obstet. Gynecol. 134, 243–249 (1979)

    CAS  PubMed  Google Scholar 

  35. C.E. Powe, M.K. Evans, J. Wenger, A.B. Zonderman, A.H. Berg, M. Nalls, H. Tamez, D. Zhang, I. Bhan, S.A. Karumanchi, N.R. Powe, R. Thadhani, Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N. Engl. J. Med. 369, 1991–2000 (2013)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  36. S. Liu, W. Tang, J. Zhou, J.R. Stubbs, Q. Luo, M. Pi, L.D. Quarles, Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J. Am. Soc. Nephrol. 17, 1305–1315 (2006)

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

Ruth M. Perez, BS, Research Associate; Michelle Scoggins, Research Assistant; Mary Billings, Health Unit Coordinator of Labor and Delivery; Sheila Phipps, Health Unit Coordinator Postpartum.

Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Aurora Research Institute, Aurora Sinai Medical Center, 960 N. 12th Street, Suite 4120, Milwaukee, Wisconsin, 53233

    Ahmed Dalmar & Maharaj Singh

  2. Endocrine Research Laboratory, Aurora St. Luke’s Medical Center—Aurora Research Institute, Milwaukee, Wisconsin

    Hershel Raff

  3. Medical College of Wisconsin, Milwaukee, Wisconsin

    Hershel Raff

  4. Department of Obstetrics and Gynecology, University of Texas-Houston, Houston, Texas, USA

    Suneet P. Chauhan

  5. Department of Obstetrics and Gynecology, Aurora Sinai Medical Center, Milwaukee, Wisconsin

    Danish S. Siddiqui

  6. University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin

    Danish S. Siddiqui

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  1. Ahmed Dalmar
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Correspondence to Ahmed Dalmar.

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Dalmar, A., Raff, H., Chauhan, S.P. et al. Serum 25-hydroxyvitamin D, calcium, and calcium-regulating hormones in preeclamptics and controls during first day postpartum. Endocrine 48, 287–292 (2015). https://doi.org/10.1007/s12020-014-0296-9

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  • DOI: https://doi.org/10.1007/s12020-014-0296-9

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